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DDR2 (T654M), Active(D06-12G)

DDR2 (T654M), Active(D06-12G)

  • $226.00


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Description :Recombinant human DDR2 (T654M) (467-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :467-end (T654M)

Genbank Number :NM_006182

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :~70 kDa

Gene Aliases :TKT; NTRKR3; TYRO10

Scientific Background :DDR2 is a member of a novel subclass of RTKs containing a distinct extracellular region encompassing a factor VIII-like domain (1) and is thought to be involved in the regulation of cell growth, differentiation, and metabolism. DDR2 plays a role in the regulation of collagen turnover mediated by smooth muscle cells in obstructive diseases of blood vessels and the lung (2).

References :
1. Karn, T. et al: Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. Oncogene 8: 3433-3440, 1993.

2. Ferri, N. et al: Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Am J Pathol. 2004 May;164(5):1575-85.

Product Sheets (By Lot #) :

T1028-3.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, NfkB Pathway, Receptor Tyrosine Kinases, Cancer, Cardiovascular Disease, NfkB Pathway, Apoptosis/Autophagy, Receptor Tyrosine Kinases