DCAMKL2, Active(D15-11G)

DCAMKL2, Active(D15-11G)

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Description :Recombinant human DCAMKL2 (1-690) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-690

Genbank Number :NM_001040261

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~105 kDa

Gene Aliases :DCLK2; DCK2; DCDC3; DCDC3B; DKFZp761I032; MGC45428

Scientific Background :DCAMKL2 (also known as doublecortin-like kinase 2 or DCLK2) is a close homologue of doublecortin or DCX which is associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly. DCX; DCLK2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. DCX and DCLK2 are co-expressed in developing hippocampus, and, in their absence, there is dosage-dependent disrupted hippocampal lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations leading to reduced inhibitory synaptic tone (1).

References :
1. Kerjan G. Et al: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6766-71.

Product Sheets (By Lot #) :

H041-1.pdf

Research Areas :Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases