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Dasatinib(S19-901B)

Dasatinib(S19-901B)

  • $61.00


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Description :SRC & BCR-ABL inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :302962-49-8

Molecular Formula :C22H26ClN7O2S

Appearance :White to off-white solid

Melting Point :274-276oC

Molecular Weight :488.0

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (200 mg/ml)

Aliases :
1. N-(2-chloro-6-methylphneyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide;

2. BMS-354825

Storage and Stability :Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 2 months.

Scientific Background :Inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.61, 3.0 and 8.5 nM respectively (1,2). Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells (3).

References :
1. LJ Lombardo et al. J. Med. Chem. 2004 47:6658

2. S Nam et al. Cancer Res. 2005 65:9185

3. FM Johnson et al. Clin. Cancer Res. 2005 11:6924

Molecular Structure :

Product Sheets (By Lot #) :

T2257-51.pdf

Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Cytoplasmic Tyrosine Kinases