Dabrafenib(B08-901)

Dabrafenib(B08-901)

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Description :B-Raf(mutant V600E) inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :1195765-45-7

Molecular Formula :C23H20F3N5O2S2

Appearance :Off-white powder

Molecular Weight :519.6

Purity :>98% (TLC); NMR (conforms)

Solubilization :May be dissolved in DMSO (30 mg/ml); or ethanol (1 mg/ml, warm)

Aliases :N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide; GSK2118436

Storage and Stability :Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 3 months.

Scientific Background :Selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively)1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors.

References :
1. J Huang et al. J. Hematol. Oncol. 2013 6:1

2. C Ji et al. Drug Des. Dev. Ther. 2016 10:2491

3. R Herr et al. Cancer Res. 2015 75:216

Molecular Structure :

Product Sheets (By Lot #) :

D3370-15.pdf

Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JAK/STAT Pathway, Ser/Thr Kinases