DGKD, Active (D23-10H)
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Description : Recombinant full-length human DGKD was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag
Species : Human
Tag: HIS tag
Expression System: Sf9 insect cells using baculovirus
Sequence: Full length
Genbank Number: NM_003648.
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight : 138 kDa
Gene Aliases : DGKdelta, DGKD-2, DAGKdelta
Scientific Background : Diacylglycerol kinase delta (DGKD) is a member of DGK family type II which have a pleckstrin homology domain instead of the EF-hand motif in addition to two cysteine-rich regions (C1 domain) in the regulatory domain. These enzymes catalyze the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins such as protein kinase C isoforms and RAS guanyl nucleotide-releasing proteins and some transient receptor potential channels.(1) DGK delta is involved in cell proliferation and glucose metabolism, and has been associated with certain cancers, diabetes and epilepsy.(2)
References :
- Sakane, F. et al. (1997) Diacylglycerol kinase J. Biol. Chem. 29, 1139-1143.
- Sakai, H. et al. (2012). Recent progress on type II diacylglycerol kinases: the physiological functions of diacylglycerol kinase, δ, η and κ their involvement in disease. J Biochem. 152(5):397-406.
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Research Areas: Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, PKA/PKC Pathway,