Anti-DYRK1A(D09-63R)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the DYRK1A protein
Cited Applications :WB, ELISA, IF
Cross Reactivity :Human and Mouse
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :DYRK1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human DYRK1A.
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of DYRK1A in HeLa cell lysate with DYRK1A antibody at (A) 1 and (B) 2 ug/mL.
Sample Data :Immunocytochemistry of DYRK1A in HeLa cells with DYRK1A antibody at 10 ug/mL.
References :
1. Park J et al: Two key genes closely implicated with the neuropathological characteristics in Down Syndrome: DYRK1A and RCAN1. BMB Reports 2009; 42:6-15.
2. Park J et al: Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J. Biol. Chem. 2010; 285:31895-906
3. Li D et al: Direct association of Sprouty-related protein with and EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J. Biol. Chem. 2010; 285:35374-85.
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Research Areas :AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Invasion/Metastasis, Ser/Thr Kinases