DDR2, Active(D06M-11BG)
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Description :Recombinant mouse DDR2 (467-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag
Species :Mouse
Tag :GST
Expression System:Sf9 insect cells using baculovirus
Sequence :467-end
Genbank Number :NP_072075
Alternative Name(s) :TKT; NTRKR3; TYRO10
Formulation :Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 25% glycerol.
Storage and Stability :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Scientific Background :DDR2 is a member of a novel subclass of RTKs containing a distinct extracellular region encompassing a factor VIII-like domain (1) and is thought to be involved in the regulation of cell growth, differentiation, and metabolism. DDR2 plays a role in the regulation of collagen turnover mediated by smooth muscle cells in obstructive diseases of blood vessels and the lung (2).
References :1. Karn, T. et al: Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. Oncogene 8: 3433-3440, 1993.
2. Ferri, N. et al: Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Am J Pathol. 2004 May;164(5):1575-85.
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Molecular Weight :Observed MW ~70 kDa. Calculated MW ~70 kDa.
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