CZC-54252 HCl(L10-901)

CZC-54252 HCl(L10-901)

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Description :LRRK2 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :1199911-27-9

Molecular Formula :C22H25ClN6O4S ∙ HCl

Appearance :Off-white solid

Melting Point :N/A

Molecular Weight :541.5

Purity :≥98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (50 mg/ml)

Aliases :N-[-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl) phenyl] amino]-4-pyrimidinyl] amino] phenyl] methanesulfonamide hydrochloride

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.

Scientific Background :Novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM (1). Attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM) (1). The G2019S mutant is a common mutation found in familial Parkinson’s disease patients (2). Cell permeable.

References :
1. LH Wang et al. J. Immunol. 1999 162:3897

2. N Meydan et al. Nature 1996 379:645

Molecular Structure :

Product Sheets (By Lot #) :

T2257-77.pdf

Research Areas :Neurobiology, Neurobiology