Due to Xmas holidays, our last days of shipping will be as follow: International Dec 18, 2020. USA: Dec 21, 2020. The shipments will resume as usual on International: Jan 8, 2021 and USA: Jan 4, 2021.
CYLD, Active (C578-380G)

CYLD, Active (C578-380G)

  • $226.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :  Recombinant human CYLD (1-956) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species : Human

Tag : GST tag

Expression System : Sf9 insect cells

Sequence : 1-956

Genbank Number : NM_015247

Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Activity Assay, Western Blot

Molecular Weight :  135 kDa

Gene Aliases :  EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2

Scientific Background : CYLD is a cytoplasmic deubiquitinating enzyme, which removes ubiquitin molecules from various signaling proteins, and regulates the activities of many cellular and signaling processes. It plays a role in the regulation of inflammation, immunity, cell cycle progression, spermatogenesis, osteoclastogenesis, ciliogenesis, migration and tumorigenesis. (1) Several signaling pathways, such as the Nuclear Factor-kB (NF-kB), Wnt/β-catenin and c-Jun N-terminal kinase (JNK) pathways, and potentially others have been linked with or regulated by CYLD. (2) Mutations in CYLD gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. (3)

References : 
1. Bignell G.R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet. 25(2):160–165, 2000.

2. Verhoeft, K.R. et al The cylindromatosis (CYLD) gene and head and neck tumorigenesis. Cancers Head Neck. 1: 10, 2016.

3. EntreZ Gene: CYLD cylindromatosis (turban tumor syndrome)

Product Sheets: (by Lot #):

N3580-9.pdf

Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder