Cyclin Y Protein(C87-30G)
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Description :Recombinant human Cyclin Y (2-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :NM_145012
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~65 kDa
Gene Aliases :CCNY; C10orf9; CBCP1; CCNX; CFP1
Scientific Background :Cyclin Y belongs to the highly conserved cyclin family. The members of the cyclin family are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclin Y plays an important role in the processes of transcription, DNA repair, and cell cycle progression. Cyclin Y regulates cyclin-dependent kinases (1). Cyclin Y is an isoform of CCNY that is also known as CFP1 variant A which has a calculated molecular mass of 36.9 kD. (2). Cyclin Y specifically activates transcription through the MYC promoter.
1. Li, X. et.al: Identification and characterization of cyclin X which activates transcriptional activities of c-Myc. Molec. Biol. Rep. 36: 97-103, 2009.
2. Myc. Molec. Biol. Rep. 36: 97-103, 2009. Deloukas, P. et.al: DNA sequence and comparative analysis of human chromosome 10. Nature 429: 151-157, 2004.
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Research Areas :Cancer, Cell Cycle, Cancer, Cell Cycle