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CSK, Active(C63-10U)

CSK, Active(C63-10U)

  • $226.00


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Description :Recombinant full-length tag-free human CSK was expressed by baculovirus in Sf9 insect cells.

Species :Human

Tag :Tag-free

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_004383

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~52 kDa

Gene Aliases :MGC117393

Scientific Background :CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus (1). A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells (2). This association is highly specific and it is speculated that PEP may be an effector and/or regulator of CSK in T cells and other hemopoietic cells.

References :
1. Partanen, J. et al: Cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416-src). Oncogene 6: 2013-2018, 1991.

2. Cloutier, J.-F. et al: Association of inhibitory tyrosine protein kinase p50(csk) with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J. 15: 4909-4918, 1996.

Product Sheets (By Lot #) :

K137-1.pdf

Research Areas :Cancer, Inflammation, Cytoplasmic Tyrosine Kinases, Cancer, Inflammation, Cytoplasmic Tyrosine Kinases