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Description :Recombinant full length human CRYAA was expressed in E. coli cells using an N-terminal His tag.
Tag :HIS tag
Sequence :Full Length
Genbank Number :NM_000394
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~21 kDa
Gene Aliases :CRYA1; HSPB4
Scientific Background :CRYAA or crystallin alpha A is the major protein components of the vertebrate eye lens which is composed of 2 primary gene products--alpha-A and alpha-B. CRYAA can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family (1). CRYAA plays an important role in the normal embryologic development of the anterior segment of the eye. In the Elo mouse, a 1-bp deletion in the gamma-E-crystallin gene causes autosomal dominant cataract and microphthalmia (2).
1. Moormann, R. J. et.al: Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene. Proc. Nat. Acad. Sci. 79: 6876-6880, 1982.
2. Cartier, M. et.al: A frameshift mutation in the gamma-E-crystallin gene of the Elo mouse. Nature Genet. 2: 42-45, 1992. Note: Erratum: Nature Genet. 2: 343 only, 1992.
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Research Areas :Cancer, Metabolic Disorder, Neurobiology, Cancer, Neurobiology, Metabolic Disorder