CPTH2(K311-903B)

CPTH2(K311-903B)

  • $116.00


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Description :HAT Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :357649-93-5

Molecular Formula :C14H14ClN3S

Appearance :white powder

Molecular Weight :291.80

Purity :>98% (TLC)

Solubilization :May be dissolved in DMSO (>25 mg/ml)

Aliases :Cyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl]hydrazone

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to one month.

Scientific Background :CPTH2 is a selective inhibitor of the histone acetyltransferase Gcn5P both in vitro and in vivo (IC50 = 0.800 uM)1. In vitro, the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3. In vivo it decreased acetylation of bulk histone H3 at the H3-AcK14 site.

References :
1. F Chimenti et al. J. Med. Chem. 2009 52:530

Molecular Structure :

Product Sheets (By Lot #) :

P3320-11.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway