FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :HAT Inhibitor
CAS Registry Number :357649-93-5
Molecular Formula :C14H14ClN3S
Appearance :white powder
Molecular Weight :291.80
Purity :>98% (TLC)
Solubilization :May be dissolved in DMSO (>25 mg/ml)
Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to one month.
Scientific Background :CPTH2 is a selective inhibitor of the histone acetyltransferase Gcn5P both in vitro and in vivo (IC50 = 0.800 uM)1. In vitro, the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3. In vivo it decreased acetylation of bulk histone H3 at the H3-AcK14 site.
1. F Chimenti et al. J. Med. Chem. 2009 52:530
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway