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Description :Recombinant human COMT (27-271) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :NM_000754
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :53 kDa
Gene Aliases :HEL-S-98n
Scientific Background :Catechol O-methyltransferase (COMT) is a major catabolic regulator of synaptic catecholamine neurotransmitters and it catalyzes the transfer of a methyl group to catecholamines and degrades dopamine, norepinephrine and epinephrine. The two forms of COMT (soluble COMT [S-COMT] and membrane-bound COMT [MB-COMT]) encoded by a single gene located on 22q11.2 have been identified. Activation of COMT affects the biological half-lives of certain neuroactive drugs.
1. Pivac N, et al: The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Genes Brain Behav. 2011;10(5):565–9
2. Wardle MC, et al: Does COMT genotype influence the effects of d-amphetamine on executive functioning? Genes Brain Behav. 2013;12(1):13–20.
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Research Areas :Cancer, Neurobiology