CID-2011756(P72-901)

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Description :PKD1 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :638156-11-3

Molecular Formula :C22H21ClN2O3

Appearance :Tan powder

Melting Point :189-192oC

Molecular Weight :396.9

Purity :≥98% (TLC); NMR (Conforms)

Solubilization :Soluble in DMSO (>50mg/ml); or ethanol (8mg/ml, warm).

Aliases :5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl) phenyl]-2-furancarboxamide

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent and selective ATP-competitive inhibitor of protein kinase D (PKD). IC50=3.2, 0.6 and 0.7 uM for PKD1, 2 and 3 respectively. Inhibits phorbol ester-induced PKD activation in LNCaP prostate cancer cells. Cell permeable.

References :
1. ER Sharlow et al. PLoS One 2011 6:e25134

Molecular Structure :

Product Sheets (By Lot #) :

T2257-79.pdf

Research Areas :Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Ser/Thr Kinases