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CHIR-99021(G09-901B)

CHIR-99021(G09-901B)

  • $50.00


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Description :GSK3 beta inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :252917-06-9

Molecular Formula :C22H18Cl2N8

Appearance :Tan colored powder

Melting Point :N/A

Molecular Weight :465.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/ml, warm)

Aliases :6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl] amino] ethyl] amino]-3-pyridinecarbonitrile

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months

Scientific Background :Potent and selective inhibitor of glycogen synthase kinase-3beta(GSK3beta, IC50 = 5 nM) and GSK3alpha (IC50 = 10 nM) (1). Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells (2). Promotes replication and survival of pancreatic beta cells (3). Enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors (4). Cell permeable and active in vivo.

References :
1. CN Bennett et al. J. Biol. Chem. 2002 277:30998

2. CN Bennett et al. PNAS 2005 102:3324

3. R Mussmann et al. J. Biol. Chem. 2007 282:12030

4. AP Manceur et al. Exp. Cell. Res. 2011 317:2086

Molecular Structure :

Product Sheets (By Lot #) :

T2257-33.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Invasion/Metastasis