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CDKL3 Protein(C45-30G)

CDKL3 Protein(C45-30G)

  • $215.00


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Description :Recombinant full-length human CDKL3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_001113575

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~98 kDa

Gene Aliases :NKIAMRE

Scientific Background :CDKL3 or cyclin-dependent kinase-like 3 is a member of cyclin-dependent protein kinase (CDK) family which is highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and is known to be important regulators of cell cycle progression and cellular proliferation. CDKL3 is a novel CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases (1). CDKL3 is identified as a gene absent in leukemic patients with chromosome 5q deletion and this loss may be an important determinant of dysmyelopoiesis (2).

References :
1. Yee, K. W. L. et.al: NKIAMRE, a novel CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. Biochem. Biophys. Res. Commun. 308: 784-792, 2003.

2. Midmer, M. et.al: Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion. Cancer Res. 59: 4069-4074, 1999.

Product Sheets (By Lot #) :

O760-1.pdf

O928-1.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases