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CDK7/CyclinH1/MNAT1, Active(C36-10H)

CDK7/CyclinH1/MNAT1, Active(C36-10H)

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Description :Recombinant full-length human CDK7, Cyclin H1 and MNATI were co-expressed by baculovirus in Sf9 insect cells using N-terminal His tags.

Species :Human

Tag :HIS tags

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_001799

Genbank Number 2 :NM_001239

Genbank Number 3 :NM_002431

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~40kDa, Cyclin H1 ~39kDa, and MNAT1 ~37kDa

Gene Aliases :CDK7: CAK1, STK1, CDKN7, p39MO15 Cyclin H1: CCNH, CAK, p34, p37 MNATI: MAT1, RNF66

Scientific Background :CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).

References :
1. Fisher, R. P.;A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994.

2. Larochelle, S. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007.

Product Sheets (By Lot #) :

E287-1.pdf

H2678-6.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases