CDK11A (CDC2L2)/CyclinD3 Protein(C24-35CG)
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Description :Recombinant human CDK11A (361-end) and full-length CyclinD3 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tags
Expression System:Sf9 insect cells using baculovirus
Sequence :361-end (CDK11A) and Full length (CyclinD3)
Genbank Number :NM_024011
Genbank Number 2 :NM_001760
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :CDK11A ~73 kDa, and Cyclin D3 ~58 kDa
Gene Aliases :CDK11A: CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE
Scientific Background :CDK11A or cyclin-dependent kinase 11A is a member of the p34Cdc2 protein kinase family. CDKs are known to be essential for eukaryotic cell cycle control. CDK11A gene complex may harbor one or more tumor suppressor genes affected by chromosome 1p36 modifications in neuroblastoma (1). CDK11A is associated with the alpha and beta isoforms of cyclin L1 and L2 in a high molecular mass complex that shows splicing activity (2). CDK11A can be cleaved by caspases and this is demonstrated to play a role in cell apoptosis.
1. Lahti, J. M. et.al: Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet. 7: 370-375, 1994.
2. Loyer, P. et.al: Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J. Biol. Chem. 283: 7721-7732, 2008.
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Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases