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CDC42BPG (DMPK2), Active(D17-11G)

CDC42BPG (DMPK2), Active(D17-11G)

  • $226.00


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Description :Recombinant human CDC42BPG (1-475) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-475

Genbank Number :NM_017525

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~78 kDa

Gene Aliases :DMPK2; HSMDPKIN; KAPPA-200; MRCKG; MRCKgamma

Scientific Background :Serine/threonine-protein kinase MRCKγ, encoded by CDC42BPG gene, acts as a downstream effector of CDC42 in cytoskeletal reorganization, and contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and MLC2 phosphorylation. It belongs to AGC protein kinase family, DMPK subfamily. It contains an N-terminal kinase domain, followed by a coiled-coil domain, a second coiled-coil domain containing a kinase inhibitory motif (KIM), a variable region, a cysteine-rich domain, a pleckstrin (PLEK; 173570) homology (PH) domain, a citron (605629) homology (CNH) domain, and a C-terminal CDC42 (116952)/RAC (602048) interactive binding (CRIB) domain.

References :
1. Ng, Y. et al: Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. J. Biol. Chem. 279: 34156-34164, 2004.

2. Kedra D. et al: The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Hum Genet. 100(5-6):611-9, 1997.

Product Sheets (By Lot #) :

K1624-3.pdf

Research Areas :Cancer, Cardiovascular Disease, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases