HDAC1, Active (H83-30G)
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Description : Full-length recombinant human HDAC1 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full Length 323-end
Genbank Number : NM_004964
Specific Activity : Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : HDAC Assay, Western Blot
Molecular Weight : ~88 kDa
Gene Aliases : HD1, RPD3, GON-10, RPD3L1, DKFZp686H12203
Scientific Background : HDAC1 or Histone deacetylase 1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex which plays a key role in the regulation of eukaryotic gene expression (1). HDAC1 interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis. HDAC1 is an essential element of the co-activation system for IFN-induced gene regulation and antiviral responses (2).
1. Bauer, W. R. et.al : Nucleosome structural changes due to acetylation. J. Molec. Biol. 236: 685-690, 1994.
2. Nusinzon, I. et.al : Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Nat. Acad. Sci. 100: 14742-14747, 2003.
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Research Areas: Cancer, Cell Cycle, Inflammation