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CDC25C, Active(C04-20CG)

CDC25C, Active(C04-20CG)

  • $226.00


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Description :Full-length recombinant human CDC25C was expressed in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :BC019089

Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Phosphatase Assay, Western Blot

Molecular Weight :~84 kDa

Gene Aliases :CDC25

Scientific Background :CDC25C (also known as cell division cycle 25 homolog C) is a member of the CDC25 phosphatase family. CDC25C is highly conserved during evolution and it plays a key role in the regulation of cell division. CDC25C activates the partially purified p34 (cdc2)/cyclin B complex and directs the dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis (1). CDC25C also suppresses p53-induced growth arrest. The regulation of CDC25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation (2).

References :
1. Gould, K. L. et.al: Complementation of the mitotic activator, p80(cdc25), by a human protein-tyrosine phosphatase. Science 250: 1573-1576, 1990.

2. Bulavin, D. V. et.al: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411: 102-107, 2001.

Product Sheets (By Lot #) :

H140-1.pdf

I074-2.pdf

Research Areas :Phosphatases, Cell Cycle, Cancer, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases