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Cardiotrophin-1 (CT-1)(C801-40N)

Cardiotrophin-1 (CT-1)(C801-40N)

  • $193.00


Description :Recombinant Human Cardiotrophin-1 (CT-1) was expressed in E. coli cells.

Species :Human

Expression System:E.coli

Genbank Number :Q16619

Storage, Stability and Shipping :The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :<1.0 EU/μg of recombinant protein as determined by the LAL method.

Molecular Weight :21.0 kDa

Reconstitution Protocol :Reconstitute in sterile HCl at 100µg/mL (containing at least 0.1% human or bovine serum albumin).

Scientific Background :Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine.

Sample Cell Assay Data :ED50 is ≤ 1.0 ng/mL as determined by the dose-dependent TF-1 cell proliferation.

Purity :Recombinant Human Cardiotrophin-1 (CT-1)) resolved on a 15% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.

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Research Areas :Cancer