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Cantharidin (P16-902C)

Cantharidin (P16-902C)

  • $59.00


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Description : Phosphatase PP2A Inhibitor

CAS Registry Number: 56-25-7

Molecular Formula : C10H12O4

Appearance : White powder

Molecular Weight : 196.20

Purity : >98% (HPLC)

Solubilization : May be dissolved in DMSO (20 mg/ml); or ethanol (5 mg/ml)

Aliases : 3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione

Storage and Stability :  Store as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 weeks.

Scientific Background : Inhibits protein phosphatase 2A (Ki=0.19 uM) and PP1 (Ki=1.1 uM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via phosphorylation and degradation of β-catenin2. Arrests G2/M transition via JNK/Sp1-dependent down-regulation of CDK13. Cell permeable.

References : 
1. RE Honkanen FEBS Lett. 1993 330:283
2. MY Wu et al. Oncol. Rep. 2014 32:513
3. FR Gong et al. Oncotarget 2015 6:18469

Molecular Structure : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Product Sheets (By Lot #):

P3320-9.pdf

Research Areas: Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases,