FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Recombinant full-length human CaMKPase was expressed in E. coli cells using an N-terminal GST tag.
Tag :GST tag
Sequence :Full Length
Genbank Number :NM_014634
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~74 kDa
Gene Aliases :PPM1F, FEM-2, hFEM-2, KIAA0015, POPX2
Scientific Background :CaMKPase is a member of the PP2C family of Ser/Thr protein phosphatases that dephosphorylate and regulate the multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) (1). The multifunctional CaMKs mediate cellular responses induced by increases in second messenger Ca2+ and have been implicated in the control of synaptic transmission, gene transcription, cell growth and contraction of cardiac and smooth muscles (2). Overexpression of CaMKPase has been shown to mediate caspase-dependent apoptosis. CaMKPase can also interact with the Rho guanine nucleotide exchange factors (PIX) thereby blocking the effects of p21-activated kinase 1 (PAK1).
1. Isamu, K. et al: Phosphorylation and activation of Ca2+/calmodulin-dependent protein kinase phosphatase by Ca2+/calmodulin-dependent protein kinase II. FEBS Letters,1999; 456: 249-252.
2. Ishida, A. et al: Stimulation of Ca2+/calmodulin-dependent protein kinase phosphatase by polycations. Archives of Biochemistry and Biophysics, 2002; 408:229-238.
Product Sheets (By Lot #) :
Research Areas :Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Phosphatases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Phosphatases