CD147 (22-205) Protein (C81D7-G651H)
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Description: Recombinant human CD147 (22-205) protein was expressed in CHO cells using a C-terminal His-tag.
Species :Human
Tag : His tag
Expression System:CHO cells
Sequence :22-205
Genbank Number :NM_198589
Activity :Binding ability measured in a functional ELISA. CD147 (22-205) protein (His tag) can bind to immobilized 2019-nCoV spike protein RBD (Fc-tag) (C19SD-G241F).
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight :30-36 kDa
Gene Aliases :Basigin, EMMPRIN
Scientific Background :CD147 is a highly glycosylated transmembrane protein that acts as the main upstream stimulator of matrix metalloproteinases (MMPs) (1). It has been reported to bind viral Spike protein of SARS-Co-2, thereby playing a functional role in mediating the viral invasion of the host cell. CD147 also acts as an RBC receptor for Plasmodium falciparum, a Malarial protozoan (2). In addition, expression level of CD147 is increased in tumor tissue, inflammation and pathogenically infected cells. Therefore, CD147 receptor blocking drugs may provide novel therapeutic strategy against viral invasion, such as 2019-nCoV (3).
References :
1. Kong LM, et al: A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis. Cancer Research. 2014, 74(14):3764-78.
2. Wang K, et al SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. BioRxiv. 2020 doi: https://doi.org/10.1101/2020.03.14.988345
3. Ulrich H, et al: CD147 as a target for COVID-19 treatment: Suggested effects of azithromycin and stem cell engagement.
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