CDKL2 Protein(C44-30G)

CDKL2 Protein(C44-30G)

  • $215.00


Description :Recombinant full-length human CDKL2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_003948

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~81 kDa

Gene Aliases :KKIAMRE; P56

Scientific Background :CDKL2 or cyclin-dependent kinase-like 2 is a member of a large family of CDC2-related serine/threonine protein kinases that is postnatally expressed in various brain regions. The extremely high CDKL2 expression in brain regions suggests that it has a role in cognition and emotion. CDKL2 transcripts increase in the deep cerebellar nuclei of the rabbit after eyeblink conditioning, a model of associative learning and memory CDKL2, also known as p56 KKIAMRE, accumulates primarily in the cytoplasm with lower levels in the nucleus (1). CDKL2 or p56, and the related protein kinase had a similar pattern of mRNA expression except in the reproductive organs. CDKL2 is expressed in several human tissues, with the highest expression in testis and kidney (2).

References :
1. Meyerson, A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917, 1992.

2. Taglienti, C. A. Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. Oncogene 13: 2563-2574, 1996.

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Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases