CDK7/CyclinH1, Active(C36-102H)

CDK7/CyclinH1, Active(C36-102H)

  • $226.00


Description :Recombinant full-length human CDK7 and Cyclin H1 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tags.

Species :Human

Tag :His tags

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_001799

Genbank Number 2 :NM_001239

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :CDK7 ~41~43 kDa, and Cyclin H1 ~39 kDa

Gene Aliases :CDK7: CAK1, STK1, CDKN7, p39MO15
Cyclin H1: CCNH, CAK, p34, p37

Scientific Background :CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).

References :
1. Fisher, R. P.: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994.

2. Larochelle, S.: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007.

Product Sheets (By Lot #) :



Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases