CDK2/CyclinO, Active(C29-19G)
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Description :Recombinant full-length human CDK2/Cyclin O was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_001798
Genbank Number 2 :NM_021147
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :CDK2 ~58 kDa and Cyclin O ~68 kDa
Gene Aliases :CDK2: p33 (CDK2) CyclinO: CCNO; CCNU; UDG2
Scientific Background :CDK2/CyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity (1). CDK2/CyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle (2).
References :
1. Caradonna, S. et.al: Affinity purification and comparative analysis of two distinct human uracil-DNA glycosylases. Exp. Cell Res. 222: 345-359, 1996.
2. Muller, S. J. et.al: Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. J. Biol. Chem. 268: 1310-1319, 1993.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases