2019-nCoV Spike protein S1 (D614G) (C19S1-G231H)

2019-nCoV Spike protein S1 (D614G) (C19S1-G231H)

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Description: Recombinant 2019-nCoV Spike protein S1 (D614G) (16-685) was expressed in CHO cells using a C-terminal His-tag.

Species: Virus

Tag : His tag

Expression System:CHO cells

Sequence :16-685

Genbank Number : MN908947

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Assay Data :Sample activity Data. For specific information on a given lot, see the related technical datasheet.

Assay Data : Sample activity Data. For specific information on a given lot, see the related technical datasheet.

Molecular Weight :125 kDa

Gene Aliases : 2019-nCoV s1, SARS-CoV-2 spike S1, SARS-CoV-2 S1, novel coronavirus spike s1, nCov spike s1, coronavirus spike S1

Scientific Background: Novel coronavirus SARS-CoV-2 has caused the pandemic of respiratory diseases (COVID-19) around the world in 2020 (1). The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits, S1 and S2 is known to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2) (2). Recently, a variant of SARS-CoV-2 carrying D614G mutation in the Spike protein has become the most prevalent form in the global pandemic. This G614 variant of Spike protein has been associated experimentally with higher infectivity and clinically with higher viral loads in infected individuals (3).

References :

1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.
2. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. Nature. 2020, 581:215-220.
3. Korber B, et al: Tracking changes in SARS-CoV-2 Spike: Evidence that D614G increases infectivity of the covid-19 virus. Cell. 2020, 182:812-82.

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