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c-JUN Protein(J05-55G)

c-JUN Protein(J05-55G)

  • $215.00


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Description :Recombinant human c-JUN (1-79) was expressed in E.coli cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :1-79

Genbank Number :NM_002228

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~35 kDa

Gene Aliases :AP1

Scientific Background :c-Jun is a proto-oncogene that forms a complex with c-Fos which regulates transcription from promoters containing AP-1 activation elements (1). c-Jun has specific DNA binding activity and following in vitro translation, c-Jun binds as a homodimer to the AP-1 DNA site. The transactivating function of c-Jun is acutely regulated by a wide variety of cellular signals via modulation of phosphorylation of two serines (63 and 73). Jun N-terminal domain kinases (JNKs), are responsible for mediating S63/73 phosphorylation on c-Jun in response to a variety of cellular stimuli including TNF-a, heat stress and u.v. light (2).

References :
1. Halazonetis, T D. et al: c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinitie. Cell. 1988 Dec 2;55(5):917-24.

2. Dai, T. et al: Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function. Oncogene. 1995 Mar 2;10(5):849-55.

Product Sheets (By Lot #) :

E287-3.pdf

Research Areas :Neurobiology, Inflammation, Cardiovascular Disease, JNK/SAPK Pathway, NfkB Pathway, Apoptosis/Autophagy, Cellular Stress, Neurobiology, Inflammation, Cardiovascular Disease, JNK/SAPK Pathway, NfkB Pathway, Apoptosis/Autophagy, Cellular Stress