C-646(K311-903)

C-646(K311-903)

  • $116.00


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Description :HAT Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :328968-36-1

Molecular Formula :C24H19N3O6

Appearance :Orange powder

Melting Point :224-226oC

Molecular Weight :445.4

Purity :>98%

Solubilization :May be dissolved in DMSO (10 mg/ml)

Aliases :4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid

Storage and Stability :Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM )1. Induces apoptosis in prostate cancer cells2. Enhances fear extinction memory and synaptic plasticity in mice3. Promotes tau deacetylation reducing levels of pathogenic p-tau4. Cell permeable.

References :
1. EM Bowers et al. Chem. Biol. 2010 17:471

2. FR Santer et al. Mol. Cancer Ther. 2011 10:1644

3. R Marek et al. J. Neurosci. 2011 31:7486

4. S-W Min et al. Neuron 2010 67:953

Molecular Structure :

Product Sheets (By Lot #) :

P3320-8.pdf

Research Areas :Cancer, Cell Cycle, Inflammation, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway