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BMP-4(B853-40N)

BMP-4(B853-40N)

  • $204.00


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Description :Human active form BMP-4 (293-408) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Species :Human

Tag :

Expression System:E.coli

Sequence :293-408

Genbank Number :NP_001193.2

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :Less than 0.1 ng/ug (IEU/ug) of BMP-4.

Molecular Weight :~13.5 kDa

Gene Aliases :ZYME; BMP2B; OFC11; BMP2B1; MCOPS6; BMP4

Scientific Background :BMP4 is a member of the bone morphogenetic protein family that is part of the transforming growth factor-beta superfamily. BMP4 plays an important role in the onset of endochondral bone formation in humans and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva (1). BMP4 acts as a novel, noncytotoxic therapeutic effector that is used to prevent growth and recurrence of glioblastomas in humans (2).

References :
1. Kan, L., et.al: Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am. J. Path. 165: 1107-1115, 2004.

2. Piccirillo, S. G. M. et.al: Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444: 761-765, 2006.

Product Sheets (By Lot #) :

I111-6.pdf

Research Areas :AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, WNT Signaling, Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, PKA/PKC Pathway, WNT Signaling, Invasion/Metastasis