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BMP-2(B851-40N)

BMP-2(B851-40N)

  • $204.00


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Description :Human active form BMP-2 (283-396) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Species :Human

Tag :

Expression System:E.coli

Sequence :283-396

Genbank Number :NP_001191.1

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :Less than 0.1 ng/ug (IEU/ug) of BMP-2.

Molecular Weight :~13.8 kDa

Gene Aliases :BMP2A

Scientific Background :BMP-2 is a member of the bone morphogenetic protein family that is part of the transforming growth factor-beta (TGFB) superfamily. BMP-2 acts as a disulfide-linked homodimer that induces bone and cartilage formation. BMP2 modulates fibroblast-like synoviocyte cell populations in inflamed synovium (1). BMP2 plays a role in human T-cell differentiation and involve in the long bone formation (2).

References :
1. Lories, R. J. U. et.al: Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum. 48: 2807-2818, 2003.

2. Cejalvo, T. et.al: Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology 121: 94-104, 2007.

Product Sheets (By Lot #) :

I111-5.pdf

Research Areas :AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, WNT Signaling, Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, PKA/PKC Pathway, WNT Signaling, Invasion/Metastasis