BML-277(C48-901)

BML-277(C48-901)

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Description :CHK2 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :516480-79-8

Molecular Formula :C20H14ClN3O2

Appearance :Off white solid

Melting Point :N/A

Molecular Weight :363.8

Purity :≥98% (TLC; 1:1 ethylacetate: hexane; Rf=0.17); NMR (Conforms)

Solubilization :May be dissolved in DMSO (20 mg/ml); or Ethanol (20 mg/ml)

Aliases :
1. 2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

2. Chk2 Inhibitor II

Storage and Stability :Storage, Stability and Shipping

Scientific Background :A highly selective inhibitor of Chk2 (IC50=15 nM). Displays <25% inhibition of 35 other kinases at 10 uM) (1). It possesses potent radioprotective activity and prevents apoptosis of human T-cells subjected to ionizing radiation (EC50= 3-7.6 μM) (1). It is a useful tool for determining the role of Chk2 in cellular signaling (2).

References :
1. K L Arienti et al. J. Med. Chem. 2005 48:1873

2. Y Pereg et al. Mol. Cell. Biol. 2006 26:6819

Molecular Structure :

Product Sheets (By Lot #) :

T2257-5.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases