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BML-259(C33-901)

  • $72.00


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Description :CDK5/p25 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :267724-00-2

Molecular Formula :C14H16N2OS

Appearance :White powder

Melting Point :150-152oC

Molecular Weight :260.4

Purity :>98% (TLC: 5% CH3OH/CH2Cl2; Rf=0.46); NMR (Conforms)

Solubilization :May be dissolved in DMSO (>25 mg/ml) or DMF (30 mg/ml)

Aliases :N-(5-Isopropylthiazol-2-yl) phenylacetamide

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Potent inhibitor of CDK5/p25 (IC50=64 nM). Inhibits CDK2/cyclin E at slightly higher concentration (IC50=98nM) (1). Protects cells against NAC-amyloid-induced cell death (2). Cell permeable.

References :
1. CJ Helal et al. Bioorg. Med. Chem. Lett. 2004 14:5521

2. A Kazmierczak et al. Neurochem. Int. 2011 58:206

Molecular Structure :

Product Sheets (By Lot #) :

T2257-6.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases