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BIX-01294 3HCl  (S344-903)

BIX-01294 3HCl (S344-903)

  • $105.00


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Description :Histone Methyl Transferase Inhibitor

Species :

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Expression System:

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CAS Registry Number :935693-62-2

Molecular Formula :C28H38N6O2.3HCl

Appearance :Off-white crystalline powder

Molecular Weight :600.02

Purity :>98%

Solubilization :May be dissolved in water (50 mg/ml) or DMSO (50 mg/ml)

Aliases :2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride

Storage and Stability :Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 uM) as well as GLP HMTase (IC50 = 38 uM) leading to a decrease in H3K9Me2 (histone H3 lysine 9 methylation) in vitro1. It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming2. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells3. It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells4.

References :
1. S Kubicek et al. Mol. Cell 2007 25:473

2. D Huangfu et al. Nat. Biotechnol. 2008 26:7105

3. Y Shi et al. Cell Stem Cell 2008 2:525

4. Z Lu et al. Anticancer Drugs 2013 24:484

Molecular Structure :

Product Sheets (By Lot #) :

P3320-5.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology