BAY 11-7082(C51-900)

BAY 11-7082(C51-900)

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Description :IKK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :19542-67-7

Molecular Formula :C10H9NO2S

Appearance :White powder

Melting Point :128-130oC

Molecular Weight :207.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (>25mg/ml) or ethanol (15 mg/ml)

Aliases :(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months

Scientific Background :Inhibits cytokine -induced IkB-alpha phosphorylation via inhibition of IkB Kinase. Inhibits IFNalpha production and blocks nuclear translocation of IRF7. Cell permeable.

References :
1. JW Pierce et al. J. Biol.Chem. 1997 272:21096

2. SA Park et al. Cancer Res. 2009 69:2416

3. R Miyamoto et al. Arthritis Res. Ther. 2010 12:R87

Molecular Structure :

Product Sheets (By Lot #) :

T2257-34.pdf

Research Areas :Inflammation, AKT/PKB Pathway, p38 Pathway, Apoptosis/Autophagy