AXL, Active(A34-11H)

AXL, Active(A34-11H)

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Description :Recombinant human AXL (473-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Species :Human

Tag :His tag

Expression System:Sf9 insect cells using baculovirus

Sequence :473-end

Genbank Number :NM_021913

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~55 kDa

Gene Aliases :UFO, JTK11

Scientific Background :AXL is a member of the receptor tyrosine kinase family which has oncogenic potential and is implicated in human myeloid leukemia (1). AXL is a member of a complex signaling network that is involved in the control of cell proliferation and differentiation. Overexpression of AXL cDNA in NIH 3T3 cells induces neoplastic transformation of these cells with the concomitant appearance of a 140kDa AXL tyrosine-phosphorylated protein (2). Expression of AXL cDNA in the baculovirus system results in the expression of the appropriate recombinant protein that is recognized by antiphosphotyrosine antibodies, confirming that the AXL protein is tyrosine phosphorylated.

References :
1. O'Bryan, J.P. et al: Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31.

2. Janssen, J.W. et al:, A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20.

Product Sheets (By Lot #) :

B1926-10.pdf

B1926-11.pdf

E3177-11.pdf

Research Areas :Cancer, Angiogenesis, Receptor Tyrosine Kinases, Cancer, Angiogenesis, Receptor Tyrosine Kinases