AS-041164(P29-901)

AS-041164(P29-901)

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Description :PI3K gamma inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :6318-41-8

Molecular Formula :C11H7NO4S

Appearance :Yellow Solid

Melting Point :N/A

Molecular Weight :249.2

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/mL)

Aliases :
1. 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione

2. NSC31098

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for 1 month.

Scientific Background :A selective PI 3-Kgamma isoform inhibitor (IC50 = 0.24, 1.45, 0.07 and 1.70 uM for alpha, beta, gamma and delta isoforms respectively). Blocks neutrophil recruitment and displays anti-inflammatory activity (1). Active in vivo.

References :
1. C Ferrandi et al. J. Pharmacol. Exp. Ther. 2007 322:923

Molecular Structure :

Product Sheets (By Lot #) :

T2257-15.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Lipid Kinases