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AR-A014418(G09-901)

AR-A014418(G09-901)

  • $105.00


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Description :GSK3beta inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :487021-52-3

Molecular Formula :C12H12N4O4S

Appearance :Off white powder

Melting Point :N/A

Molecular Weight :308.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (30 mg/ml)

Aliases :N-[(4-Methoxyphenyl) methyl]-N'-(5-nitro-2-thiazolyl) urea

Storage and Stability :Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20°C for up to 2 months.

Scientific Background :Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50=104 nM). Inhibits beta-amyloid-mediated neurodegeneration in hippocampal slices. Antiinflammatory activity. Cell permeable. Active in rodent models.

References :
1. R Bhat et al. J. Biol. Chem. 2003 278: 45937

2. SH Ramirez et al. Am. J. Pathol. 2010 176:881

Molecular Structure :

Product Sheets (By Lot #) :

T2257-31.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Invasion/Metastasis