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Apigenin(K10-900C)

Apigenin(K10-900C)

  • $39.00


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Description :Kinase inhibitor (pan)

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :520-36-5

Molecular Formula :C15H10O5

Appearance :Yellow powder

Melting Point :345-390oC

Molecular Weight :270.2

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (50 mg/ml)

Aliases :4',5,7-Trihydroxyflavone

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Selective CK2 inhibitor. Inhibits proliferation of Wnt-1 transfected cells and suppresses phosphorylation of beta-catenin. Ameliorates renal dysfunction at 20 mg/Kg in a rat model of glomerulonephritis. Cell permeable and active in vivo.

References :
1. J Shen et al. J. Immunol. 2001 167:4919

2. DH Song et al. J. Biol. Chem. 2000 275:23790

3. M Yamada et al. Proc. Natl. Acad. Sci. USA 2005 102:7736

Molecular Structure :

Product Sheets (By Lot #) :

T2257-32.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, PKA/PKC Pathway, WNT Signaling, Apoptosis/Autophagy, Cell Cycle, Cellular Stress, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases, Cytoplasmic Tyrosine Kinases, Receptor Tyrosine Kinases