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APICIDIN(H83-904B)

APICIDIN(H83-904B)

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Description :HDAC Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :183506-66-3

Molecular Formula :C34H49N5O6

Appearance :white solid

Melting Point :190oC

Molecular Weight :623.78

Purity :≥98%

Solubilization :Soluble in DMSO (10 mg/ml); or ethanol (1 mg/ml)

Aliases :Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]

Storage and Stability :Stable for at least 1 year after receipt when stored, as supplied, at -20oC. Stock solutions are stable for up to 3 months at -20oC.

Scientific Background :Cyclopeptide inhibitor of histone deactylases (HDACs)1. Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1)2. Decreases HIF1alpha protein levels and transcriptional activity in human and mouse tumor cell lines3. Cell permeable.

References :
1. SJ Darkin-Rattray et al. Proc. Natl. Acad. Sci. USA. 1996 93:13143

2. JW Han et al. Cancer Res. 2000 60:6068

3. SH Kim et al. Oncol. Rep. 2007 17:647

Molecular Structure :

Product Sheets (By Lot #) :

P3320-4.pdf

Research Areas :Cancer, Cell Cycle, Inflammation