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Anti-UBLE1A (SAE1)(U208-63R)

Anti-UBLE1A (SAE1)(U208-63R)

  • $325.00


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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the UBLE1A (SAE1) protein

Cited Applications :WB, ELISA

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :UBLE1A antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human UBLE1A

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of UBLE1A in SK-N-SH lysate with UBLE1A antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

Scientific Background :UBLE1A (also known as SAE1) or SUMO1 activating enzyme subunit 1 is involved in regulating protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (1). The SAE1/SAE2 dimer functions in SUMO1 activation in a manner analogous to the single E1 ubiquitin-activating enzymes. The SAE2 inactivation may be a therapeutic strategy in MYC-driven cancers (2).

References :
1. Okuma, T. et.al: In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochem. Biophys. Res. Commun. 254: 693-698, 1999.

2. Kessler, J. D. et.al: A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science 335: 348-353, 2012.

Product Sheets (By Lot #) :

O2121-29.pdf

Research Areas :Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, Neurobiology, Cancer, Neurobiology, Cell Cycle, Cytoplasmic Tyrosine Kinases