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Anti-UBE2N (UBC13)(U231-63R)

Anti-UBE2N (UBC13)(U231-63R)

  • $325.00


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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the UBE2N (UBC13) protein

Cited Applications :WB, ELISA, IF, IHC

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :UBE2N (UBC13) antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UBE2N (UBC13).

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of UBE2N in human small intestine cell lysates with UBE2N antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.

Sample Data :Immunohistochemistry of UBE2N in mouse thymus tissue with UBE2N antibody at 2 ug/ml.

Scientific Background :UBE2N (UBC13) or ubiquitin-conjugating enzyme E2N is a member of the E2 ubiquitin-conjugating enzyme family which plays a role in DNA post-replication repair. UBE2N gene encodes a novel human E2 that may be involved in protein degradation in the muscles and testis (1). UBE2N plays a role in initiation of homologous recombination during double-strand break repair (2). UBE2N activity may have therapeutic uses in controlling inflammatory responses and it is also important in the induction of immune responses.

References :
1. Yamaguchi, T. et.al: Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. J. Biochem. 120: 494-497, 1996.

2. Zhao, G. Y. et.al: A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Molec. Cell 25: 663-675, 2007.

Product Sheets (By Lot #) :

O2109-31.pdf

Research Areas :Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, Neurobiology, Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, Neurobiology, Cancer, Neurobiology, Cell Cycle, Cytoplasmic Tyrosine Kinases