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Anti-STK39 (STLK3)(S51-63BR)

Anti-STK39 (STLK3)(S51-63BR)

  • $325.00


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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the STK39 (STLK3) protein

Cited Applications :WB, ELISA, IHC

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :STK39 antibody was raised against a 18 amino acid synthetic peptide from near the center of human STK39

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of STK39 in rat brain tissue lysate with STK39 antibody at (A) 1 and (B) 2 ug/ml.

Sample Data :Immunohistochemistry of STK39 in human brain tissue with STK39 antibody at 2.5 ug/ml.

Scientific Background :STK39 (also known as serine threonine kinase 39) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress (1). STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure (2).

References :
1. Johnston, A. M. et.al: SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene 19: 4290-4297, 2000.

2. Chen LY. et.al: STK39 is an independent risk factor for male hypertension in Han Chinese. Int J Cardiol, 2010 Oct 1.

Product Sheets (By Lot #) :

O2121-17.pdf

Research Areas :Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases