HOLIDAY SHIPPING UPDATE: All delivery service requests will not be processed on Monday, July 1, 2019 as it is Canada Day holiday. Regular delivery schedule will resume the next business day.
Anti-STAT5(S56-63BR)

Anti-STAT5(S56-63BR)

  • $347.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the STAT5 protein

Cited Applications :WB

Cross Reactivity :Western blot STAT5 from human cells

STAT5 from other species may also be detectable.

Host  :Rabbit

Immunogen :Synthetic peptide corresponding to amino acids 692-696 of human STAT5 (protein accession number P42229)

Purification :Affinity Chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Representative western blot with Anti-STAT5 (1:1000) using 5 ng of human recombinant STAT1β, STAT2, STAT3, STAT4, STAT5 and STAT6.

Sample Data :Representative western blot with Anti-STAT5 (1:1000) using 3 μg, 10 μg and 30 μg of K562 cell lysate.

Scientific Background :STAT5 (signal transducers and activators of transcription 5) is a member of the STAT family. It is phosphorylated by receptor associated protein kinases in response to cytokines and growth factors (1). The differentiation of T helper cells is regulated by members of the STAT family. In BCR-ABL-positive cells, STAT5 is constitutively activated by tyrosine phosphorylation. STAT5 activation results in upregulation of Bcl-XL and increased resistance to induction of apoptosis. STAT5 is involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6 betahydroxylase (2).

References :
1. Wang, D. et al: Naturally occurring dominant negative variants of Stat5. Molec. Cell Biol. 16: 6141-6148, 1996.

2. A Subramanian et al: STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase. Nucleic Acids Res. 1998; 26(9): 2173–2178.

Product Sheets (By Lot #) :

R027-9.pdf

Research Areas :Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy