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Description :Rabbit Polyclonal Antibody
Specificity :Recognizes the STAT1 protein
Cited Applications :WB
Cross Reactivity :Western blot of human STAT1
STAT1B from other species may also be detectable.
Immunogen :Synthetic peptide corresponding to amino acids 699-703 of human STAT1
Purification :Affinity chromatography
Stability :Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Representative western blot with Anti-STAT1β (1:1000) using 20 ng of GST-tagged human recombinant STAT1β, STAT2, STAT3, STAT4, STAT5, and STAT6.
Sample Data :Representative western blot with Anti-STAT1β (1:1000) using 30 μg of Jurkat and THP1 cell lysate.
Scientific Background :STAT1β is a member of the signal transducers and activators of transcription (STAT) family of proteins that carry out a dual function: signal transduction and activation of transcription. STAT1β transcription factor is specific for the IFN pathway and plays a central role in mediating many, if not all, IFN-dependent biological responses (1). Presence of STAT1β leads to an efficient antiviral response when cells were infected with virus suggesting that a STAT-dependent pathway is activated following virus infection by endogenously produced IFN. Virus-induced STAT protein translocation from the cytoplasmic compartment can be detected within 3 h of infection.
1. Improta, T. et al: Susceptibility to virus infection is determined by a Stat-mediated response to the autocrine effect of virus-induced type I interferon. Cytokine. 1997 Jun;9(6):383-93.
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Research Areas :Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy, Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy