HOLIDAY SHIPPING UPDATE: All delivery service requests will not be processed on Wednesday, July 1, 2020 as it is Canada Day holiday. Regular delivery schedule will resume the next business day.
Anti-SHP2(P38-63R)

Anti-SHP2(P38-63R)

  • $270.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the SHP2 (PTPN11) protein

Cited Applications :WB

Cross Reactivity :Western blot human and mouse SHP2

SHP2 from other species may also be detectable.

Host  :Rabbit

Immunogen :Synthetic peptide corresponding to amino acids 578-582 of human SHP2

Purification :Affinity Chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Representative Western blot with Anti-SHP2 (1:1000) using 20ng of GST-tagged human recombinant SHP1 and SHP2.

Sample Data :Representative Western blot with Anti-SHP2 (1:1000) using 3 μg, 10 μg and 30 μg of Jurkat cell lysate.

Scientific Background :PTPN11 (SHP2) is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain (1). This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration (2). Mutations in this gene are a cause of Noonan syndrome, Cardiofacio-cutaneous Syndrome as well as acute myeloid leukemia.

References :
1. Dechert, U. et al: Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. Hum. Genet. 96: 609-615, 1995.

2. Ahmad, S. et al: A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Nat. Acad. Sci. 90: 2197-2201, 1993.

Product Sheets (By Lot #) :

M168-1.pdf

Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases, Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases