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Anti-PTPN11 (SHP2)(P38-63CR)

Anti-PTPN11 (SHP2)(P38-63CR)

  • $325.00


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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the PTPN11 protein

Cited Applications :WB, ELISA, IF

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :PTPN11 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human PTPN11.

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of PTPN11 in mouse skeletal muscle tissue lysate with PTPN11 antibody at (A) 0.5 and (B) 1 ug/ml.

Scientific Background :Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain (1). This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration (2)

References :
1. Dechert, U. et al: Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. Hum. Genet. 96: 609-615, 1995.

2. Ahmad, S. et al: A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Nat. Acad. Sci. 90: 2197-2201, 1993.

Product Sheets (By Lot #) :

O2109-58.pdf

Research Areas :Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Phosphatases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Phosphatases